Introduction
An event series for Turing-Roche partnership updates, knowledge sharing and new perspectives. Find out more about the series.
This month we will be hearing from Robert Beckman, M.D., Professor of Oncology and of Biostatistics, Bioinformatics, and Biomathematics at Georgetown University Medical Center.
He will tell us about Dynamic Precision Medicine: A New Approach to Cancer Therapy Resistance.
This event will be held in hybrid form - you can join us in the Enigma room at Floor 1 of the Alan Turing Institute.
About the event
Genetic heterogeneity within an individual cancer is even greater than previously recognized. Rare subclones, below the level of detection by current DNA sequencing methods, are a major source of therapy resistance and moderate to late term relapse.
Dynamic precision medicine (DPM) is a proactive approach to designing personalized treatment sequences that delay relapse and prolong survival.
This talk will present mathematical modeling, computer simulation, and emerging experimental data about genetic heterogeneity in cancer and DPM. Ongoing work on developing clinical study designs to efficiently test these ideas will be discussed, as well as the potentially critical future roles of digital twins, data science, and artificial intelligence and machine learning in these efforts.