Healthcare and aerospace experts at King's College London, The Alan Turing Institute, the University of Cambridge, and the Oden Institute for Computational Engineering and Sciences at UT Austin in Texas have said advances in digital twin technology make it a powerful tool for facilitating predictive and precision medicine and enhancing decision-making for aerospace systems. Their opinion piece was published today in Nature Computational Science.

Digital twins, a virtual version of real-life objects that can be used to predict how that object will perform, have the potential to transform many different technologies with a wide range of real-life applications. When applied to healthcare, the digital twin, could predict how a patient’s disease will develop and how patients are likely to respond to different therapies.

Digital twin of a heart. Credit: Greg Foss, Texas Advanced Computing Center

It is also of huge benefit in aerospace, where, for example, the technology will be needed to monitor and control thousands of drones, ensuring that they are maintained, have efficient and safe flight plans and can automatically adapt to changes in conditions, such as weather, without the need for human interaction.

However, current digital twins are largely the result of bespoke technical solutions that are difficult to scale.

The authors say that these use cases place new demands on the speed, robustness, validation, verification and uncertainty quantification in digital twin creation workflows.

Achieving digital twins at scale will require a drastic reduction in technical barriers to their adoption.

Lead author Professor Steven Niederer from the School of Biomedical Engineering & Imaging Sciences, King’s College London said in medicine, the digital twin will allow testing of a large number of therapies on a patient to identify the best option for that individual with their unique disease.

"There is, however, a need to invest in the underlying theory for how to make models, how to run these models at speed and how to combine multiple models together to ensure that they run as expected,” he said.

“We also need to further develop the mathematics of how we create digital twins from patient data, how we measure uncertainty in patient data, and how to account for uncertainty in the model in predictions. These are all things which need further investment.”

“We are making more measurements in patients in the hospital and from remote monitoring and we need to develop methods for rapidly and robustly combining this patient information into a digital twin to provide a single representation of the patient.”

“Another challenge is how do we get better at predicting how the heart will operate under extreme conditions. We often want to predict when the heart will fail, however, we only have information that is obtained from them under normal operating procedures.”

Similarly from an aerospace perspective, Dr Karen Willcox, Director, Oden Institute for Computational Engineering and Sciences at The University of Texas at Austin, said in order to be useful, the digital twin must be predictive and quantify uncertainty.

“Digital twins must be able to analyse ‘what if’ scenarios and issue predictions about the future, in order to guide decision making to manage a physical asset. That means the digital twin cannot be built on data alone, it needs to include both data and predictive models,” she said.

Even though many open challenges remain, the value of digital twins is clear. And they don't have to be perfect to be valuable. “Even with existing limitations, digital twins are providing valuable decision support in many different application areas,” said Dr Willcox “Ultimately we would like to see  the technology  used in  every engineering system. At that point we can start thinking not just about how a digital twin might change the way we operate the system, but also how we design it in the first place.”

“The Digital Twin represents a new paradigm in the modeling and simulation of the heart for both basic and clinical translational goals,” said Michael Sacks, professor of biomedical engineering and director of the Oden Institute's Willerson Center for Cardiovascular Modeling and Simulation. “Unlike traditional modeling wherein we develop a ‘static’ version of the state of the heart, a cardiac digital twin is continuously updated with patient and population data. It can then be used in near real time simulations to detect and predict functional anomalies for improved patient diagnosis and treatment. The ongoing challenges that remain include large-scale human data integration, including dealing with regulatory and privacy issues, and major advancements in the development of near real time cardiac simulation.”

Mark Girolami, Programme Director for Data-Centric Engineering at The Alan Turing Institute said: “The promise of data driven coupling of mathematical models with the physical reality they represent, the so-called digital twin, is going to be transformational in how we interact with and control the physical world. In healthcare for instance, the increasing power of computers and algorithms are enabling technologies to build a patient-specific digital twin, catering to our diversity as human beings and improving individual health outcomes. However, these promised advances are going to be hard won, requiring further concerted and sustained foundational research and development to fully realise the promise of the digital twin."

"...these promised advances are going to be hard won, requiring further concerted and sustained foundational research and development to fully realise the promise of the digital twin."

Adrian Smith, Institute Director and Chief Executive of The Alan Turing Institute added: "This Nature Computational Science perspective marks an important step in elevating digital twin research into more and more critical application areas, including healthcare. There is now a need for important thinking around standard setting and the responsible rollout of new uses of this technology as possibilities open up.

“The Alan Turing Institute has long been a proponent of the massive potential for digital twins to make our world safer, smarter and more efficient. This international collaboration, involving researchers from across the UK and the US, takes us ever closer to scaling digital twins from bespoke and artisanal to a major feature of industry that will impact our everyday lives.”
 


Read the paper in Nature Computational Science.

Citation: Niederer, S.A., Sacks, M.S., Girolami, M. et al. Scaling digital twins from the artisanal to the industrial. Nat Comput Sci 1, 313–320 (2021). https://doi.org/10.1038/s43588-021-00072-5

Digital heart image photo credit Greg Foss, Texas Advanced Computing Center