Probabilistic Models for Integration Error in the Assessment of Functional Cardiac Models


This paper studies the numerical computation of integrals, representing estimates or predictions, over the output f(x) of a computational model with respect to a distribution p(dx) over uncertain inputs x to the model. For the functional cardiac models that motivate this work, neither f nor p possess a closed-form expression and evaluation of either requires ≈ 100 CPU hours, precluding standard numerical integration methods.

Our proposal is to treat integration as an estimation problem, with a joint model for both the a priori unknown function f and the a priori unknown distribution p. The result is a posterior distribution over the integral that explicitly accounts for dual sources of numerical approximation error due to a severely limited computational budget. This construction is applied to account, in a statistically principled manner, for the impact of numerical errors that (at present) are confounding factors in functional cardiac model assessment.

Citation information

Oates CJ, Niederer S, Lee A, Briol F-X, Girolami M. Probabilistic Models for Integration Error in Assessment of Functional Cardiac Models. Advances in Neural Information Processing Systems (NIPS 2017).