Mark Iles is Associate Professor in Leeds Institute for Data Analytics at the University of Leeds. From degrees from the University of Bristol and University of Reading, he completed his PhD in Genetic Epidemiology at the University of Leeds in 2000, following which he worked as a Lecturer in the School of Medicine at the University of Sheffield and a Senior Scientist at the Karolinska Institute in Stockholm. He has been at Leeds since 2005, where his research focuses on the development and application of statistical methods to the analysis of population-based genetic data.
Mark Iles was a member of the analysis team for the first genome-wide association study (GWAS) of coronary artery disease (CAD) that formed part of the Wellcome Trust Case Control Consortium (WTCCC 2007). As well as being the first GWAS of CAD (Samani et al, 2007), the overall WTCCC served as a proof-of-principle that GWAS could identify common genetic variants contributing to the risk of a range of common diseases. Mark's major applied research interest has been the genetics of Melanoma and I chair the analysis team for the largest melanoma consortium in the world (GenoMEL).
Mark Iles' research interests are in the area of genetic epidemiology analysis, both theoretical and applied, with a particular interest in population genetics considerations and the design of genetic association studies. Current interests include the use of polygenic scores for trait prediction and the analysis of highly structured populations (non-random mating).